What is IDP®?
The proteins in IDP® are the natural defense proteins isolated from fresh, pasteurised milk.
IDP® consists of a specific subset of whey proteins that naturally exist in milk. These proteins are made up of essential amino acids that can form part of a healthy diet.
The IDP® proteins are freeze dried after extraction to ensure nutritional and natural bioactive properties are maintained.
In addition to their role in supporting the nutritional properties of milk, IDP® defense proteins support the body's immune system.
IDP® works with the innate (acute phase) immune system within the body to help normalize the inflammatory response. It does this through its unique, powerful and synergistic Triple A Action (anti-inflammatory, antioxidant, antimicrobial), providing two lines of defense: antioxidant and antimicrobial activity, and anti-inflammatory activity.
The science of IDP®
IDP® has significant anti-inflammatory effects when compared with known anti-inflammatory agents.
These effects have been observed at concentrations within the range of typical dosages and, in some cases, at levels lower than accepted agents. IDP® was independently tested by Trinity Bioactives (July 2009, Wellington, New Zealand) using an activated neutrophil inhibition study.
Anti-inflammatory properties were determined by measuring the ability to inhibit inflammatory markers, tumor necrosis factor (TNF-α) and interleukin (IL-6), which are produced by lipopolysaccharide (LPS) activated neutrophils.
The efficacy of IDP® was referenced against a control and the drug chloroquine, a known inhibitor of TNF-α and IL-6 production. It was also compared against:
- Curcumin, the reported anti-inflammatory component of the spice turmeric
- Diclofenac, a powerful anti-inflammatory drug incorporated into over-the-counter and prescription products such as Voltaren
- Aspirin, a common pain reliever
The results of the study show IDP® with equivalent efficacy to Aspirin at the same concentration, while IDP® also compares well to an albeit lower dose of the powerful anti-inflammatory Diclofenac.
IDP® ranks within the top 10 dried antioxidant fruits, vegetables and spices as indicated by the USDA combined ORAC (Oxygen Radical Absorbance Capacity) value.
IDP® is a potent inhibitor of harmful pathogens, but is relatively ineffective against many commensal and probiotic species. These unique properties enable IDP® to work with the body's microbiome, supporting the microorganisms we need to support our health while inhibiting pathogens that can cause infections. These selective antimicrobial properties together with its soothing anti-inflammatory and healing antioxidant effects are particularly helpful for:
- Conditions caused by yeasts Candida and Malassezia, such as eczema and psoriasis that are the result of an excessive inflammatory response to infection
- Serious skin and wound infections caused by bacteria such as Staphylococci and Streptococci
- Acne, which is caused by the growth of Propionibacterium acnes in hair follicles, with the recruitment of white blood cells resulting in pimples.
- Gut health, supporting the intestinal barrier and probiotic microflora
Development of NMR: Natural Mastitis Remedy
Mastitis continues to be an issue for the dairy industry due to economic losses as a result of lowered production, discarded milk, drug and vet costs and downgraded milk quality.
Current antibiotic-based treatments have not decreased the incidence of mastitis in lactating dairy cows, which still range from 28-35 clinical cases per 100 cows per lactation.
We have developed a new antimicrobial formulation for the prevention and treatment of mastitis in dairy cows – NMR. As a naturally derived formulation, NMR requires no withholding period for milk.
The formulation is based on our proprietary fraction of milk that has powerful anti-microbial activity and strong antioxidant and anti-inflammatory properties. Taken from normal milk in healthy animals, this fraction is based on the cow’s natural immune defense system, which is present to protect the cow from mastitic infection.
One of the key advantages listed for the most well-known milk-derived bioactives, lactoferrin and lactoperoxidase, is their antimicrobial activity. Our research discovered that the inhibitory effects against mastitis pathogens diminished as the cationic bioactive fractions, such as Lf and Lp, became more purified. Since these proteins comprise the bulk of the mammary gland’s immune defense protein system, it followed that there would be synergistic actions between other discrete bioactives, which leads to a successful immune response. This led to the discovery that concentrating, rather than purifying, these immune defense proteins resulted in a successful naturally-derived inhibitory product.
The result - a natural mastitis formulation that is:
- Based on the innate immune defense proteins present in milk
- A powerful antimicrobial, anti-inflammatory and antioxidant
- Not an antibiotic and doesn’t require milk withholding
- Completely safe for intramammary administration into lactating dairy cows
- Shown to be effective against mastitis-causing organisms
IDP® for Digestive Health Research
Quantec is currently collaborating with AgResearch and High-Value Nutrition (HVN) on “IDP® for Digestive Health”, a research project designed to investigate the potential of developing a novel IDP®-based food product for improved digestive health.
In the gut health market, consumers are looking for products that support digestive and immune health, while also being ‘natural’. IDP® has been used as a key ingredient to develop food and beverage (F&B) products in the form of milk powder sachets and protein beverages that are currently sold in China and other parts of Asia.
The team will utilise in vitro cell based model systems to help understand what effects consuming IDP® can have on the intestinal barrier. They will also investigate whether IDP® in combination with probiotic bacteria can provide synergistic health benefits. The primary investigator for the project is Dr Dulantha Ulluwishewa from AgResearch Ltd.
Read more about the project here.